A 58-year-old male presented with an asymptomatic, slowly growing, cystic and mobile swelling on the left One-of-a-kind Hair-On Hides leg calf of 6 months duration.Fine-needle aspiration cytology was suggestive of epidermal inclusion cyst.Histopathological examination revealed seborrheic keratosis-like changes in the cyst wall comprising of marked acanthosis, papillomatosis, pseudohorn cysts, squamous eddies, and clumps of keratohyalin granules.This is Screens a very rare variant of epidermal inclusion cyst, possibly induced by infection with human papillomavirus.